Microglia toxicity in preterm brain injury

Microglia toxicity in preterm brain injury

Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a conseque...

P108: Microglia in Traumatic Brain Injury

Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...

Brain Injury in Preterm Infants

Zoe Iliodromiti1, Dimitrios Zygouris2, Paraskevi Karagianni3, Panagiotis Belitsos4, Angelos Daniilidis5 and Nikolaos Vrachnis6 1Neonatal Unit, 2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, Athens, 23nd Department of Obstetrics and Gynecology, University of Athens Medical School, Attiko Hospital, Athens, 32nd NICU and Neonatology Department...

Traumatic Brain Injury, Microglia, and Beta Amyloid

Recently, there has been growing interest in the association between traumatic brain injury (TBI) and Alzheimer's Disease (AD). TBI and AD share many pathologic features including chronic inflammation and the accumulation of beta amyloid (Aβ). Data from both AD and TBI studies suggest that microglia play a central role in Aβ accumulation after TBI. This paper focuses on the current research on ...

Editorial Brain Injury in Preterm Newborn Infants